The Mc.205 reached the airfields in June 1943, with the first planes assigned to the 1st Stormo based on the island of Pantelleria and utilized over North Africa and in defense of the last convoys directed to Tunisia.. On their first sortie, 25 Mc.205 faced, with excellent results, much larger enemy squadrons of P.40s and Spitfires. Later, the "Veltro" were relocated from Pantelleria to Catania where they were used in support of MAS (torpedo boat) operations. Here, they role became solely defensive in the attempt of stopping the ever increasing enemy bombers.
When the Allied forces landed in Sicily, in addition to the 10 Mc.205 deployed on the island’s airfield, there were about 50 Mc.202 and about the same number of Bf.109s. Despite the fact that more planes were sent to the front, the situation appeared immediately dramatic. The Luftwaffe has only 400 planes against the 4,900 deployed by the Allied air forces. The quick retreat from eastern Sicily, forced some of the air force personnel to destroy on the ground six of the Mc.205s based at the airport of Catania-Fontanarossa. The battle for the control of the airspace over Sicilywas short lived; heavy Allied bombing over Axis’ airfields did the job. The 4th Stormo, later reorganized in Calabria where it attempted to halt the new landing by strafing ships and landing vessels along the coast.
Meantime, the Pisa-based 51st Stormo, which had received it first Mc.205 since April 1943, was engaged in harsh fights over the Island of Sardinia. On the 2nd of August, six Mc.205 attacked 20 P.38 and P.40 engaged in the shooting of a Cant Z506 rescue plane; 6 of the Allied planes will be lost to only one Mc.205. Mussolini’s air force (Aviazione Repubblica Sociale Italiana) saw a conspicuous utilization of the Mc.205 with 29 planes retained after the armistice and 112 new one produced by the Macchi of Varese, which, later on, will be neutralized by Allied bombing | 
